Mass Spectrometry Reveals Changes in MHC I Antigen Presentation After Lentivector Expression of a Gene Regulation System

• Main Authors: Roland Vogel (Author), Reem Al-Daccak (Author), Oliver Drews (Author), Jessy Alonzeau (Author), Gabor Mester (Author), Dominique Charron (Author), Stefan Stevanovic (Author), Jacques Mallet (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The rapamycin-inducible gene regulation system was designed to minimize immune reactions in man and may thus be suited for gene therapy. We assessed whether this system indeed induces no immune responses. The protein components of the regulation system were produced in the human cell lines HEK 293T,...