Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and transdermal delivery

• المؤلفون الرئيسيون: Radwa M.A. Abd-Elal (مؤلف), Aya M. Essawy (مؤلف), Maha A. Salem (مؤلف), Mahitab Elsayed (مؤلف), Mona G. Khalil (مؤلف), Eman Abdelhakeem (مؤلف), Nouran A. Ali (مؤلف), Mai Ahmed Tawfik (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2023-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Duloxetine hydrochloride (DUL) is a BCS class-II antidepressant drug, acting via serotonin and norepinephrine reuptake inhibition. Despite high oral absorption, DUL suffers limited bioavailability due to extensive gastric and first-pass metabolism. To improve DUL's bioavailability; DUL-loaded e...