Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and transdermal delivery

Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and transdermal delivery

Duloxetine hydrochloride (DUL) is a BCS class-II antidepressant drug, acting via serotonin and norepinephrine reuptake inhibition. Despite high oral absorption, DUL suffers limited bioavailability due to extensive gastric and first-pass metabolism. To improve DUL's bioavailability; DUL-loaded e...

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Main Authors: Radwa M.A. Abd-Elal (Author), Aya M. Essawy (Author), Maha A. Salem (Author), Mahitab Elsayed (Author), Mona G. Khalil (Author), Eman Abdelhakeem (Author), Nouran A. Ali (Author), Mai Ahmed Tawfik (Author)
Format: Book
Published: Elsevier, 2023-12-01T00:00:00Z.
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