Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and transdermal delivery

• Hlavní autoři: Radwa M.A. Abd-Elal (Autor), Aya M. Essawy (Autor), Maha A. Salem (Autor), Mahitab Elsayed (Autor), Mona G. Khalil (Autor), Eman Abdelhakeem (Autor), Nouran A. Ali (Autor), Mai Ahmed Tawfik (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2023-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Duloxetine hydrochloride (DUL) is a BCS class-II antidepressant drug, acting via serotonin and norepinephrine reuptake inhibition. Despite high oral absorption, DUL suffers limited bioavailability due to extensive gastric and first-pass metabolism. To improve DUL's bioavailability; DUL-loaded e...