MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer

• Main Authors: Haowei Zhang (Author), Qixin Li (Author), Xiaolong Guo (Author), Hong Wu (Author), Chenhao Hu (Author), Gaixia Liu (Author), Tianyu Yu (Author), Xiake Hu (Author), Quanpeng Qiu (Author), Gang Guo (Author), Junjun She (Author), Yinnan Chen (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer (CRC). Cisplatin (DDP)-resistant cells exhibit an inherent ability to evade the toxic chemotherapeutic drug effects which are characterized by the activation of slow-cycle program...