MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer

• Главные авторы: Haowei Zhang (Автор), Qixin Li (Автор), Xiaolong Guo (Автор), Hong Wu (Автор), Chenhao Hu (Автор), Gaixia Liu (Автор), Tianyu Yu (Автор), Xiake Hu (Автор), Quanpeng Qiu (Автор), Gang Guo (Автор), Junjun She (Автор), Yinnan Chen (Автор)
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• Опубликовано: Elsevier, 2024-06-01T00:00:00Z.
• Предметы: article
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Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer (CRC). Cisplatin (DDP)-resistant cells exhibit an inherent ability to evade the toxic chemotherapeutic drug effects which are characterized by the activation of slow-cycle program...