Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

• Główni autorzy: Archita Agrawal (Autor), Sebastian Parlee (Autor), Diego Perez-Tilve (Autor), Pengyun Li (Autor), Jia Pan (Autor), Piotr A. Mroz (Autor), Ann Maria Kruse Hansen (Autor), Birgitte Andersen (Autor), Brian Finan (Autor), Alexei Kharitonenkov (Autor), Richard D. DiMarchi (Autor)
• Format: Książka
• Wydane: Elsevier, 2018-07-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Objective: To signal, FGF19 and FGF21 require co-receptor βKlotho (KLB) to act in concert with FGF receptors, and yet there is appreciable variance in the C-terminal sequences of these two novel metabolic hormones where binding is believed to be primary. We seek to determine the functional consequen...