Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

Objective: To signal, FGF19 and FGF21 require co-receptor βKlotho (KLB) to act in concert with FGF receptors, and yet there is appreciable variance in the C-terminal sequences of these two novel metabolic hormones where binding is believed to be primary. We seek to determine the functional consequen...

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Main Authors: Archita Agrawal (Author), Sebastian Parlee (Author), Diego Perez-Tilve (Author), Pengyun Li (Author), Jia Pan (Author), Piotr A. Mroz (Author), Ann Maria Kruse Hansen (Author), Birgitte Andersen (Author), Brian Finan (Author), Alexei Kharitonenkov (Author), Richard D. DiMarchi (Author)
Formato: Livro
Publicado em: Elsevier, 2018-07-01T00:00:00Z.
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