Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

• Main Authors: Archita Agrawal (Author), Sebastian Parlee (Author), Diego Perez-Tilve (Author), Pengyun Li (Author), Jia Pan (Author), Piotr A. Mroz (Author), Ann Maria Kruse Hansen (Author), Birgitte Andersen (Author), Brian Finan (Author), Alexei Kharitonenkov (Author), Richard D. DiMarchi (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To signal, FGF19 and FGF21 require co-receptor βKlotho (KLB) to act in concert with FGF receptors, and yet there is appreciable variance in the C-terminal sequences of these two novel metabolic hormones where binding is believed to be primary. We seek to determine the functional consequen...