Pulmonary Delivery of Favipiravir in Rats Reaches High Local Concentrations without Causing Oxidative Lung Injury or Systemic Side Effects

• Главные авторы: Ozlem Akbal-Dagistan (Автор), Mustafa Sevim (Автор), Leyla Semiha Sen (Автор), Nur Sena Basarir (Автор), Meltem Culha (Автор), Aybige Erturk (Автор), Hanan Fael (Автор), Engin Kaptan (Автор), Serap Sancar (Автор), Lutfiye Mulazimoglu Durmusoglu (Автор), Berrak C. Yegen (Автор), Ayca Yildiz-Pekoz (Автор)
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• Опубликовано: MDPI AG, 2022-11-01T00:00:00Z.
• Предметы: article
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Favipiravir displays a rapid viral clearance, a high recovery rate and broad therapeutic safety; however, its oral administration was associated with systemic side effects in susceptible patients. Considering that the pulmonary route could provide a high drug concentration, and a safer application w...