Combined Antiviral Therapy Using Designed Molecular Scaffolds Targeting Two Distinct Viral Functions, HIV-1 Genome Integration and Capsid Assembly

• Egile Nagusiak: Wannisa Khamaikawin (Egilea), Somphot Saoin (Egilea), Sawitree Nangola (Egilea), Koollawat Chupradit (Egilea), Supachai Sakkhachornphop (Egilea), Sudarat Hadpech (Egilea), Nattawat Onlamoon (Egilea), Aftab A Ansari (Egilea), Siddappa N Byrareddy (Egilea), Pierre Boulanger (Egilea), Saw-See Hong (Egilea), Bruce E Torbett (Egilea), Chatchai Tayapiwatana (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2015-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Designed molecular scaffolds have been proposed as alternative therapeutic agents against HIV-1. The ankyrin repeat protein (AnkGAG1D4) and the zinc finger protein (2LTRZFP) have recently been characterized as intracellular antivirals, but these molecules, used individually, do not completely block...