Combined Antiviral Therapy Using Designed Molecular Scaffolds Targeting Two Distinct Viral Functions, HIV-1 Genome Integration and Capsid Assembly

• Main Authors: Wannisa Khamaikawin (Author), Somphot Saoin (Author), Sawitree Nangola (Author), Koollawat Chupradit (Author), Supachai Sakkhachornphop (Author), Sudarat Hadpech (Author), Nattawat Onlamoon (Author), Aftab A Ansari (Author), Siddappa N Byrareddy (Author), Pierre Boulanger (Author), Saw-See Hong (Author), Bruce E Torbett (Author), Chatchai Tayapiwatana (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Designed molecular scaffolds have been proposed as alternative therapeutic agents against HIV-1. The ankyrin repeat protein (AnkGAG1D4) and the zinc finger protein (2LTRZFP) have recently been characterized as intracellular antivirals, but these molecules, used individually, do not completely block...