LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG2000 nanoformulation: What if traditional methods are not applicable?

LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG2000 nanoformulation: What if traditional methods are not applicable?

Endotoxin detection is an important step in drug characterization. Herein we found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride (CPT-11) and an amphiphilic molecule DSPE-mPEG2000 can interfere with the limulus amebocyte lysate assay (LAL). Furthermore, the rabbit...

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Main Authors: Yanan Jin (Author), Juanjuan Jia (Author), Chan Li (Author), Jianqi Xue (Author), Jiabei Sun (Author), Kaiyuan Wang (Author), Yaling Gan (Author), Jing Xu (Author), Yaqin Shi (Author), Xingjie Liang (Author)
Format: Book
Published: Elsevier, 2018-05-01T00:00:00Z.
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