LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG2000 nanoformulation: What if traditional methods are not applicable?

• Asıl Yazarlar: Yanan Jin (Yazar), Juanjuan Jia (Yazar), Chan Li (Yazar), Jianqi Xue (Yazar), Jiabei Sun (Yazar), Kaiyuan Wang (Yazar), Yaling Gan (Yazar), Jing Xu (Yazar), Yaqin Shi (Yazar), Xingjie Liang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2018-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Endotoxin detection is an important step in drug characterization. Herein we found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride (CPT-11) and an amphiphilic molecule DSPE-mPEG2000 can interfere with the limulus amebocyte lysate assay (LAL). Furthermore, the rabbit...