A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

• Главные авторы: Marival Bermejo (Автор), Bart Hens (Автор), Joseph Dickens (Автор), Deanna Mudie (Автор), Paulo Paixão (Автор), Yasuhiro Tsume (Автор), Kerby Shedden (Автор), Gordon L. Amidon (Автор)
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• Опубликовано: MDPI AG, 2020-01-01T00:00:00Z.
• Предметы: article
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The application of in silico modeling to predict the in vivo outcome of an oral drug product is gaining a lot of interest. Fully relying on these models as a surrogate tool requires continuous optimization and validation. To do so, intraluminal and systemic data are desirable to judge the predicted...