A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

• Main Authors: Marival Bermejo (Author), Bart Hens (Author), Joseph Dickens (Author), Deanna Mudie (Author), Paulo Paixão (Author), Yasuhiro Tsume (Author), Kerby Shedden (Author), Gordon L. Amidon (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The application of in silico modeling to predict the in vivo outcome of an oral drug product is gaining a lot of interest. Fully relying on these models as a surrogate tool requires continuous optimization and validation. To do so, intraluminal and systemic data are desirable to judge the predicted...