A Rapid and Sensitive HPLC Method for Quantitation of Paclitaxel in Biological Samples using Liquid-Liquid Extraction and UV Detection: Application to Pharmacokinetics and Tissues Distribution Study of Paclitaxel Loaded Targeted Polymeric Micelles in.....

• 主要な著者: Mahboubeh Rezazadeh (著者), Jaber Emami (著者), Abolfazl Mostafavi (著者), Mahboubeh Rostami (著者), Farshid Hassanzadeh (著者), Hojjat Sadeghi (著者), Mohsen Minaiyan (著者), Afsaneh Lavasanifar (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2015-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A simple, rapid, and sensitive reversed-phase HPLC method was developed and validated for determination of paclitaxel (PTX) in plasma, various organs and tumor tissues of tumor-bearing mice. Tissue specimens of liver, kidneys, spleen, lungs, heart and tumor were separately homogenized in normal sali...