A Rapid and Sensitive HPLC Method for Quantitation of Paclitaxel in Biological Samples using Liquid-Liquid Extraction and UV Detection: Application to Pharmacokinetics and Tissues Distribution Study of Paclitaxel Loaded Targeted Polymeric Micelles in.....

• Main Authors: Mahboubeh Rezazadeh (Author), Jaber Emami (Author), Abolfazl Mostafavi (Author), Mahboubeh Rostami (Author), Farshid Hassanzadeh (Author), Hojjat Sadeghi (Author), Mohsen Minaiyan (Author), Afsaneh Lavasanifar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A simple, rapid, and sensitive reversed-phase HPLC method was developed and validated for determination of paclitaxel (PTX) in plasma, various organs and tumor tissues of tumor-bearing mice. Tissue specimens of liver, kidneys, spleen, lungs, heart and tumor were separately homogenized in normal sali...