The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management

• Váldodahkkit: Mauricio Krause (Dahkki), Thiago Gomes Heck (Dahkki), Aline Bittencourt (Dahkki), Sofia Pizzato Scomazzon (Dahkki), Philip Newsholme (Dahkki), Rui Curi (Dahkki), Paulo Ivo Homem de Bittencourt (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Hindawi Limited, 2015-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Recent evidence shows divergence between the concentrations of extracellular 70 kDa heat shock protein [eHSP70] and its intracellular concentrations [iHSP70] in people with type 2 diabetes (T2DM). A vital aspect regarding HSP70 physiology is its versatility to induce antagonistic actions, depending...