The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management

• Autori principali: Mauricio Krause (Autore), Thiago Gomes Heck (Autore), Aline Bittencourt (Autore), Sofia Pizzato Scomazzon (Autore), Philip Newsholme (Autore), Rui Curi (Autore), Paulo Ivo Homem de Bittencourt (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 2015-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Recent evidence shows divergence between the concentrations of extracellular 70 kDa heat shock protein [eHSP70] and its intracellular concentrations [iHSP70] in people with type 2 diabetes (T2DM). A vital aspect regarding HSP70 physiology is its versatility to induce antagonistic actions, depending...