The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management

• Prif Awduron: Mauricio Krause (Awdur), Thiago Gomes Heck (Awdur), Aline Bittencourt (Awdur), Sofia Pizzato Scomazzon (Awdur), Philip Newsholme (Awdur), Rui Curi (Awdur), Paulo Ivo Homem de Bittencourt (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Hindawi Limited, 2015-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Recent evidence shows divergence between the concentrations of extracellular 70 kDa heat shock protein [eHSP70] and its intracellular concentrations [iHSP70] in people with type 2 diabetes (T2DM). A vital aspect regarding HSP70 physiology is its versatility to induce antagonistic actions, depending...