A Cell Line for Detection of Botulinum Neurotoxin Type B

• Main Authors: Aleksander Rust (Author), Ciara Doran (Author), Rosalyn Hart (Author), Thomas Binz (Author), Paul Stickings (Author), Dorothea Sesardic (Author), Andrew A. Peden (Author), Bazbek Davletov (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles. Their exquisite neuronal specificity is conferred by a multistep process of binding, internalization, cytosolic escape and cleav...