A Cell Line for Detection of Botulinum Neurotoxin Type B

• Hauptverfasser: Aleksander Rust (Verfasst von), Ciara Doran (Verfasst von), Rosalyn Hart (Verfasst von), Thomas Binz (Verfasst von), Paul Stickings (Verfasst von), Dorothea Sesardic (Verfasst von), Andrew A. Peden (Verfasst von), Bazbek Davletov (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles. Their exquisite neuronal specificity is conferred by a multistep process of binding, internalization, cytosolic escape and cleav...