Tumor p-glycoprotein correlates with efficacy of PF-3758309 in in vitro and in vivo models of colorectal cancer.

• Main Authors: Erica Lynn Bradshaw-Pierce (Author), Todd M Pitts (Author), Aik-Choon eTan (Author), Kelly eMcPhillips (Author), Mark eWest (Author), Daniel L Gustafson (Author), Charles eHalsey (Author), Leslie eNguyen (Author), Nathan V Lee (Author), Julie LC Kan (Author), Brion William Murray (Author), S. Gail eEckhardt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (P-gp), a member of the ATP-binding cassette transporter family, is overexpressed in a number of different cancers and some studies show that P-gp overexpression can be correlated to poor prognosis or therapeutic resistance. Here we sought to elucidate if PF-3758309 (PF-309), a novel...