Tumor p-glycoprotein correlates with efficacy of PF-3758309 in in vitro and in vivo models of colorectal cancer.

• Автори: Erica Lynn Bradshaw-Pierce (Автор), Todd M Pitts (Автор), Aik-Choon eTan (Автор), Kelly eMcPhillips (Автор), Mark eWest (Автор), Daniel L Gustafson (Автор), Charles eHalsey (Автор), Leslie eNguyen (Автор), Nathan V Lee (Автор), Julie LC Kan (Автор), Brion William Murray (Автор), S. Gail eEckhardt (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2013-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

P-glycoprotein (P-gp), a member of the ATP-binding cassette transporter family, is overexpressed in a number of different cancers and some studies show that P-gp overexpression can be correlated to poor prognosis or therapeutic resistance. Here we sought to elucidate if PF-3758309 (PF-309), a novel...