Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice

• Hlavní autoři: Thorsten Michael Becker (Autor), Morgana Favero (Autor), Vincenzo Di Marzo (Autor), Luigia Cristino (Autor), Giuseppe Busetto (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2017-06-01T00:00:00Z.
• Témata: article
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Objectives: In the ob/ob mouse model of obesity, chronic absence of leptin causes a significant increase of orexin (OX) production by hypothalamic neurons and excessive food intake. The altered OX level is linked to a dramatic increase of the inhibitory innervation of OX producing neurons (OX neuron...