Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

• मुख्य लेखकों: Ursula H. Neumann (लेखक), Jessica S.S. Ho (लेखक), Majid Mojibian (लेखक), Scott D. Covey (लेखक), Maureen J. Charron (लेखक), Timothy J. Kieffer (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2016-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: It has been thought that the depletion of insulin is responsible for the catabolic consequences of diabetes; however, evidence suggests that glucagon also plays a role in diabetes pathogenesis. Glucagon suppression by glucagon receptor (Gcgr) gene deletion, glucagon immunoneutralization,...