Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

• 主要な著者: Ursula H. Neumann (著者), Jessica S.S. Ho (著者), Majid Mojibian (著者), Scott D. Covey (著者), Maureen J. Charron (著者), Timothy J. Kieffer (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2016-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: It has been thought that the depletion of insulin is responsible for the catabolic consequences of diabetes; however, evidence suggests that glucagon also plays a role in diabetes pathogenesis. Glucagon suppression by glucagon receptor (Gcgr) gene deletion, glucagon immunoneutralization,...