Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

• Главные авторы: Ursula H. Neumann (Автор), Jessica S.S. Ho (Автор), Majid Mojibian (Автор), Scott D. Covey (Автор), Maureen J. Charron (Автор), Timothy J. Kieffer (Автор)
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• Опубликовано: Elsevier, 2016-08-01T00:00:00Z.
• Предметы: article
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Objective: It has been thought that the depletion of insulin is responsible for the catabolic consequences of diabetes; however, evidence suggests that glucagon also plays a role in diabetes pathogenesis. Glucagon suppression by glucagon receptor (Gcgr) gene deletion, glucagon immunoneutralization,...