Effects of Posaconazole on Tacrolimus Population Pharmacokinetics and Initial Dose in Children With Crohn's Disease Undergoing Hematopoietic Stem Cell Transplantation

• Main Authors: Xiao Chen (Author), Dongdong Wang (Author), Feng Zheng (Author), Lin Zhu (Author), Yidie Huang (Author), Yiqing Zhu (Author), Ying Huang (Author), Hong Xu (Author), Zhiping Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study explored the effects of posaconazole on tacrolimus population pharmacokinetics (PPK) in children with Crohn's disease (CD) undergoing hematopoietic stem cell transplantation (HSCT). Tacrolimus concentrations, physiological and biochemical factors, and concomitant medications f...