α-1 Antitrypsin Inhibits RANKL-induced Osteoclast Formation and Functions

• Egile Nagusiak: Mohammad Ahsanul Akbar (Egilea), David Nardo (Egilea), Mong-Jen Chen (Egilea), Ahmed S. Elshikha (Egilea), Rubina Ahamed (Egilea), Eslam M. Elsayed (Egilea), Claire Bigot (Egilea), L. Shannon Holliday (Egilea), Sihong Song (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2017-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Osteoporosis is a global public health problem affecting more than 200 million people worldwide. We previously showed that treatment with α-1 antitrypsin (AAT), a multifunctional protein with antiinflammatory properties, mitigated bone loss in an ovariectomized mouse model. However, the und...