Imperatorin Restores Chemosensitivity of Multidrug-Resistant Cancer Cells by Antagonizing ABCG2-Mediated Drug Transport

• Main Authors: Chung-Pu Wu (Author), Megumi Murakami (Author), Yen-Ching Li (Author), Yang-Hui Huang (Author), Yu-Tzu Chang (Author), Tai-Ho Hung (Author), Yu-Shan Wu (Author), Suresh V. Ambudkar (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The high expression of the ATP-binding cassette (ABC) drug transporter ABCG2 in cancer cells contributes to the emergence of multidrug resistance (MDR) in individuals afflicted with either solid tumors or blood cancers. MDR poses a major impediment in the realm of clinical cancer chemotherapy. Recen...