Validation of Pharmacological Protocols for Targeted Inhibition of Canalicular MRP2 Activity in Hepatocytes Using [<sup>99m</sup>Tc]mebrofenin Imaging in Rats
The multidrug resistance-associated protein 2 (MRP2) mediates the biliary excretion of drugs and metabolites. [<sup>99m</sup>Tc]mebrofenin may be employed as a probe for hepatic MRP2 activity because its biliary excretion is predominantly mediated by this transporter. As the liver uptake...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2020-05-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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