Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions

• প্রধান লেখক: Daniel Scotcher (লেখক), Vikram Arya (লেখক), Xinning Yang (লেখক), Ping Zhao (লেখক), Lei Zhang (লেখক), Shiew‐Mei Huang (লেখক), Amin Rostami‐Hodjegan (লেখক), Aleksandra Galetin (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2020-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Creatinine is widely used as a biomarker of glomerular filtration, and, hence, renal function. However, transporter‐mediated secretion also contributes to its renal clearance, albeit to a lesser degree. Inhibition of these transporters causes transient serum creatinine elevation, which can be mistak...