Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions

• Main Authors: Daniel Scotcher (Author), Vikram Arya (Author), Xinning Yang (Author), Ping Zhao (Author), Lei Zhang (Author), Shiew‐Mei Huang (Author), Amin Rostami‐Hodjegan (Author), Aleksandra Galetin (Author)
• Format: Book
• Published: Wiley, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Creatinine is widely used as a biomarker of glomerular filtration, and, hence, renal function. However, transporter‐mediated secretion also contributes to its renal clearance, albeit to a lesser degree. Inhibition of these transporters causes transient serum creatinine elevation, which can be mistak...