INFLUENCE OF C3435T POLYMORPHISM OF THE GENE MDR1 ON THE EFFICACY OF JUVENILE IDIOPATHIC ARTHRITIS THERAPY

• Hoofdauteurs: F. V. Rokhlina (Auteur), G. A. Novik (Auteur), N. M. Kalinina (Auteur), N. V. Bychkova (Auteur), Y. N. Filippova (Auteur), M. I. Zarayskiy (Auteur)
• Formaat: Boek
• Gepubliceerd in: Union of pediatricians of Russia, 2013-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Juvenile idiopathic arthritis (JIA) is a multifactorial disease: its pathogenesis includes immunological and genetic factors. Gene MDR1 is responsible for resistance to various cytotoxic drugs. Product of gene MDR1 - P-glycoprotein (P-gp) acts as a transmembrane pump, thus affecting action of drugs....