PEPT1-mediated prodrug strategy for oral delivery of peramivir

• Autores principales: Yongbing Sun (Autor), Wei Gan (Autor), Mingdao Lei (Autor), Wei Jiang (Autor), Meng Cheng (Autor), Junwei He (Autor), Qi Sun (Autor), Wan Liu (Autor), Lvjiang Hu (Autor), Yi Jin (Autor)
• Formato: Libro
• Publicado: Elsevier, 2018-11-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Peramivir was a novel and highly potent neuraminidase (NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability (only 3%) due to the high polarity (log P of −1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated...