PEPT1-mediated prodrug strategy for oral delivery of peramivir
Peramivir was a novel and highly potent neuraminidase (NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability (only 3%) due to the high polarity (log P of −1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated...
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Elsevier,
2018-11-01T00:00:00Z.
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