PEPT1-mediated prodrug strategy for oral delivery of peramivir

Peramivir was a novel and highly potent neuraminidase (NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability (only 3%) due to the high polarity (log P of −1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated...

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Bibliografski detalji
Glavni autori: Yongbing Sun (Autor), Wei Gan (Autor), Mingdao Lei (Autor), Wei Jiang (Autor), Meng Cheng (Autor), Junwei He (Autor), Qi Sun (Autor), Wan Liu (Autor), Lvjiang Hu (Autor), Yi Jin (Autor)
Format: Knjiga
Izdano: Elsevier, 2018-11-01T00:00:00Z.
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