PEPT1-mediated prodrug strategy for oral delivery of peramivir

• Main Authors: Yongbing Sun (Author), Wei Gan (Author), Mingdao Lei (Author), Wei Jiang (Author), Meng Cheng (Author), Junwei He (Author), Qi Sun (Author), Wan Liu (Author), Lvjiang Hu (Author), Yi Jin (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peramivir was a novel and highly potent neuraminidase (NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability (only 3%) due to the high polarity (log P of −1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated...