The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

• المؤلفون الرئيسيون: Michel Alexander Steiner (مؤلف), Carla eSciarretta (مؤلف), Anne ePasquali (مؤلف), Francois eJenck (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2013-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...