The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

• Autores principales: Michel Alexander Steiner (Autor), Carla eSciarretta (Autor), Anne ePasquali (Autor), Francois eJenck (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2013-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...