The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

• Egile Nagusiak: Michel Alexander Steiner (Egilea), Carla eSciarretta (Egilea), Anne ePasquali (Egilea), Francois eJenck (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2013-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...