The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

• 主要な著者: Michel Alexander Steiner (著者), Carla eSciarretta (著者), Anne ePasquali (著者), Francois eJenck (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2013-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...