The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

• Главные авторы: Michel Alexander Steiner (Автор), Carla eSciarretta (Автор), Anne ePasquali (Автор), Francois eJenck (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2013-12-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...