The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

• Asıl Yazarlar: Michel Alexander Steiner (Yazar), Carla eSciarretta (Yazar), Anne ePasquali (Yazar), Francois eJenck (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2013-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...