Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT

• Main Authors: SJ J. Diong (Author), Aarti Jashnani (Author), Andrew W. Drake (Author), Christine Bee (Author), Felix Findeisen (Author), Gavin Dollinger (Author), Feng Wang (Author), Arvind Rajpal (Author), Pavel Strop (Author), Peter S. Lee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTThe clinical successes of immune checkpoint blockade have invigorated efforts to activate T cell-mediated responses against cancer. Targeting members of the PVR family, consisting of inhibitory receptors TIGIT, CD96, and CD112R, has been an active area of clinical investigation. In this stud...