Regulation of mycolactone, the Mycobacterium ulcerans toxin, depends on nutrient source.

• Main Authors: Caroline Deshayes (Author), Shiva Kumar Angala (Author), Estelle Marion (Author), Irène Brandli (Author), Jérémie Babonneau (Author), Laurent Preisser (Author), Sara Eyangoh (Author), Yves Delneste (Author), Pierre Legras (Author), Chantal De Chastellier (Author), Timothy P Stinear (Author), Mary Jackson (Author), Laurent Marsollier (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Mycobacterium ulcerans, a slow-growing environmental bacterium, is the etiologic agent of Buruli ulcer, a necrotic skin disease. Skin lesions are caused by mycolactone, the main virulence factor of M. ulcerans, with dermonecrotic (destruction of the skin and soft tissues) and immunosuppr...