Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2

• Main Authors: Yi-Lin Chiu (Author), Yi-Ying Wu (Author), Robert B. Barndt (Author), Yee Hui Yeo (Author), Yu-Wen Lin (Author), Hou-Ping Sytwo (Author), Huan-Cheng Liu (Author), Yuan Xu (Author), Bailing Jia (Author), Jehng-Kang Wang (Author), Michael D. Johnson (Author), Chen-Yong Lin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Matriptase is ectopically expressed in neoplastic B-cells, in which matriptase activity is enhanced by negligible expression of its endogenous inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. HAI-1, however, is also involved in matriptase synthesis and intracellular trafficking. The...