Applying the estimand and target trial frameworks to external control analyses using observational data: a case study in the solid tumor setting

• Glavni autori: Letizia Polito (Autor), Qixing Liang (Autor), Navdeep Pal (Autor), Philani Mpofu (Autor), Ahmed Sawas (Autor), Olivier Humblet (Autor), Kaspar Rufibach (Autor), Dominik Heinzmann (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Introduction: In causal inference, the correct formulation of the scientific question of interest is a crucial step. The purpose of this study was to apply causal inference principles to external control analysis using observational data and illustrate the process to define the estimand attributes.M...