Applying the estimand and target trial frameworks to external control analyses using observational data: a case study in the solid tumor setting

• Main Authors: Letizia Polito (Author), Qixing Liang (Author), Navdeep Pal (Author), Philani Mpofu (Author), Ahmed Sawas (Author), Olivier Humblet (Author), Kaspar Rufibach (Author), Dominik Heinzmann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: In causal inference, the correct formulation of the scientific question of interest is a crucial step. The purpose of this study was to apply causal inference principles to external control analysis using observational data and illustrate the process to define the estimand attributes.M...