Hyperphosphatemia-Induced Oxidant/Antioxidant Imbalance Impairs Vascular Relaxation and Induces Inflammation and Fibrosis in Old Mice

• Main Authors: Ana Asenjo-Bueno (Author), Elena Alcalde-Estévez (Author), Mariam El Assar (Author), Gemma Olmos (Author), Patricia Plaza (Author), Patricia Sosa (Author), Patricia Martínez-Miguel (Author), María Piedad Ruiz-Torres (Author), Susana López-Ongil (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aging impairs vascular function, but the mechanisms involved are unknown. The aim of this study was to analyze whether aging-related hyperphosphatemia is implied in this effect by elucidating the role of oxidative stress. C57BL6 mice that were aged 5 months (young) and 24 months (old), receiving a s...