Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Hauptverfasser: Maria Lazaridou (Verfasst von), Evi Christodoulou (Verfasst von), Maria Nerantzaki (Verfasst von), Margaritis Kostoglou (Verfasst von), Dimitra A. Lambropoulou (Verfasst von), Angeliki Katsarou (Verfasst von), Kostas Pantopoulos (Verfasst von), Dimitrios N. Bikiaris (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2020-03-01T00:00:00Z.
• Schlagworte: article
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The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...