Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• मुख्य लेखकों: Maria Lazaridou (लेखक), Evi Christodoulou (लेखक), Maria Nerantzaki (लेखक), Margaritis Kostoglou (लेखक), Dimitra A. Lambropoulou (लेखक), Angeliki Katsarou (लेखक), Kostas Pantopoulos (लेखक), Dimitrios N. Bikiaris (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...