Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Autori principali: Maria Lazaridou (Autore), Evi Christodoulou (Autore), Maria Nerantzaki (Autore), Margaritis Kostoglou (Autore), Dimitra A. Lambropoulou (Autore), Angeliki Katsarou (Autore), Kostas Pantopoulos (Autore), Dimitrios N. Bikiaris (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2020-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...