Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Автори: Maria Lazaridou (Автор), Evi Christodoulou (Автор), Maria Nerantzaki (Автор), Margaritis Kostoglou (Автор), Dimitra A. Lambropoulou (Автор), Angeliki Katsarou (Автор), Kostas Pantopoulos (Автор), Dimitrios N. Bikiaris (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2020-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...