Comprehensive assessment of exposure to clozapine in association with side effects among patients with treatment-resistant schizophrenia: a population pharmacokinetic study

• Main Authors: Nobuyuki Nomura (Author), Kohei Kitagawa (Author), Ryuhei So (Author), Fuminari Misawa (Author), Masafumi Kodama (Author), Hiroyoshi Takeuchi (Author), Robert Bies (Author), Thomas Straubinger (Author), Christopher Banker (Author), Yuya Mizuno (Author), Masaru Mimura (Author), Hiroyuki Uchida (Author)
• Format: Book
• Published: SAGE Publishing, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: There have been scarce data on the distribution of clozapine concentrations in comparison with the recommended range (350-600 ng/ml) or their relationship with side effects among patients with treatment-resistant schizophrenia. Furthermore, no studies have assessed the association betwee...